6 out of 28
Which of the following biopsy findings has the greatest relative risk for later carcinoma?
|B||Atypical lobular hyperplasia|
|D||Intraductal papilloma |
Ans. B Atypical lobular hyperplasia REF. SCHWARTZ SURGERY 8TH EDN PG 458-465
Assessment of cancer risks:
- Some pathologic features are associated with increased cancer risk.
- No increased risk is associated with adenosis, cysts, duct ectasia, or apocrine metaplasia.
- There is a slightly increased risk with moderate or florid hyperplasia, papillomatosis, and complex fibroadenomas.
- Atypical ductal (ADH) or lobular hyperplasia (ALH) carries a 4- to 5-fold increased risk of developing cancer; the risk increases to 10-fold if there is a positive family history. Patients with increased risk should be counseled appropriately and should be followed with semiannual physical examinations and yearly mammograms.