Gram Negative Bacilli
Which of the following statements is true of cholera enterotoxin? (AIIMS Nov 2009)
|A||Appears to produce its effect by stimulating adenyl cyclase activity in mucosal cells|
|B||Causes destruction of the intestinal mucosa allowing for invasive infection|
|C||Causes a net efflux of ions and water from tissue into the lumen of the large intestine|
|D||Is a protein with a molecular weight of about 284,000|
a. The clinical correlation section of this case study summarizes the action of the V. cholerae enterotoxin quite well. It can be the cause of 20-30 L/day diarrheal output, resulting in dehydration, shock, acidosis, and death.
b. It is antigenically related to the LT of E. coli, has a molecular weight of about 84,000 daltons, does not damage the mucosa, and affects the small intestine, causing a net efflux of ions and water from tissue into the lumen.