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Physiology

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Blood

Question
7 out of 42
 

Which of the following helps in bridging the fibrin in a clot and stabilizing the clot? (AIPG 2008)



A Factor III
B Factor V

C Factor VIII
D Factor XIII

Ans. D Factor XIII Explanation :-
  1. The fundamental reaction in the clotting of blood is conversion of the soluble plasma protein fibrinogen to insoluble fibrin.
  2. The process involves the release of two pairs of polypeptides from each fibrinogen molecule.
  3. The remaining portion, fibrin monomer then polymerizes with other monomer molecules to form fibrin.
  4. The fibrin is initially a loose mesh of interlacing strands.
  5. It is converted by the formation of covalent cross-linkages to a dense, tight aggregate (stabilization ).
  6. This latter reaction is catalyzed by activated factor XIII and requires Ca 2+ .

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