Female Genital Tract
Which of the following types of ovarian tumor is likely to produce masculinizing featuresand symptoms ? (LQ)
|C||Germ cell tumor|
a. Examples of ovarian stromal tumors include thecoma, fibromas, granulosa cell tumors, and Sertoli-Leydig cell tumors.
b. Fibromas are associated with Meigs’ syndrome, which consists of an ovarian fibroma, ascites, and hydrothorax.
c. The stromal cells of the ovary are the precursors of endocrine- active cells, so it is easy to understand that neoplasms derived from these stromal cells are often associated with hormone production.
d. For example, granulosa cells normally secrete estrogens, thecal cells normally secrete androgens, and hilar cells (Leydig cells) may secrete androgens.
e. Excess androgen production in females may lead to masculinization and produce symptoms such as amenorrhea, loss of secondary female sex characteristics, and the development of secondary male characteristics, such as hirsutism, temporal balding, and deepening of the voice.
f. Ovarian tumors associated with excess androgen production include androblastomas (Sertoli-Leydig cell tumors).