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Medicine

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Neurology

Question
8 out of 14
 

Which of the following metastasize outside CNS? (AIIMS May 2010)



A Glioblastoma multiforme

B Medulloblastoma

C Ependymoblastoma

D Choroid plexus tumour

Ans. B

Medulloblastoma

Medulloblastomas are highly radiosensitive tumors of the CNS and more radiosensitive than all gliomas (Astrocytoma, Ependymoma, Glioblastoma Multiforme) whereas Glioblastomas are the least radiosensitive'

Extra Edge:

1). Medulloblastoma is a highly malignant primary brain tumor that originates in the cerebellum or posterior fossa.

2). Originally considered to be a glioma, medulloblastoma is now known to be of the family of cranial primitive neuroectodermal tumors (PNET).

3). Medulloblastoma is the most common PNET originating in the brain.

4. All PNET tumors of the brain are invasive and rapidly growing tumors that, unlike most brain tumors, spread through the CSF and frequently metastasize to different locations in the brain and spine.

Recent Advances: (AIIMS May 2010)

Chang classification staging system

1). M0 - No gross subarachnoid or hematogenous metastasis

2). M1 - Microscopic tumor cells found in CSF

3). M2 - Gross nodular seeding in cerebellum, cerebral subarachnoid space, or in the third or fourth ventricles

4). M3 - Gross nodular seeding in spinal subarachnoid space

5). M4 - Extraneuraxial metastasis.

Radiosensitive Brain Tumors in Children


1). Medulloblastomas & other PNET (Most radiosensitive)

2). Gliomas (low grade astrocytoma), ependymoma

3). Pineal blastoma

4). Craniopharyngioma

5). Germ cell tumors (pure germinoma-highly radiosensitive)


Neurology Flashcard List

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