Loading....
Coupon Accepted Successfully!

Medicine

Open Flashcards

Hematology

Question
8 out of 9
 

Which of the following feature may be used to differentiate hemophilia A from von Willebrand disease.



A Bleeding time
B Prothrombin time

C Partial thromboplastin time
D Factor VIII levels

Ans. A Bleeding time

Property

VWF

Factor VIII

Gene

Located on chromosome XII

Located on X chromosome

Inheritance

Autosomal dominant

Sex linked

Synthesis

Endothelial cells, megakaryocytes platelets (not in liver cells)

In liver cells

Function

Faciliate the adhesion of platelets to subendothelial collagen

Activation of factor X in coagulation cascade

Disease

V. W. disease

Hemophillia

Features of VWF and differences with haemophilia A

Feature

Hemophilia A

Von Willebrand Disease

1. Inheritance

x- linked recessive

Autosomal dominant

2. Factor VIIIc

Decreased

Normal

3. VWF

Normal

Decreased

4. Common Presentation

Features of clotting disorder

Skin/Mucosal bleeding -

Hemarthrosis ++

Features of bleeding disorder ± clotting disorder

Skin/Mucosal bleeding +

Hemarthrosis+

5. Bleeding Time

Normal

Prolonged

6. APTT

Prolonged

Prolonged

7. PT

Normal

Normal

8. Thrombin Time

Normal

Normal

9. Fibrinogen

Normal

Normal

10. Platelet aggregation in

11. Response to Ristocetin

Normal

Normal

Decreased

Abnormal

Extra Edge:

Parahemophilia: AR, Factor V deficiency, PT, PTT

Hemophilia C: XI deficiency, AR, aPTT is increased, PT is normal

Hematology Flashcard List

9 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)