Which of the following causes persistent leucopenia? (AIPG 2011)
(Ref. Goodman Gilman 10th eD. pg. 1418; Harrison's Principles of Internal Medicine 16th Edition TABLE 94-3)
Carmustine causes persistent neutropenia with a delayed nadir.
Carmustine of BCNU is a mustard gas-related α-chloronitrosourea compound used as an alkylating agent in chemotherapy. It is used in the treatment of several types of brain cancer (including glioma, glioblastoma multiforme, medulloblastome and astrocytoma, multiple myeloma and lymphoma (Hodgkin’s and non-Hodgkin). carmustine for injection is marketed under the name BiCNU by Bristol-Myers Squibb.