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Physiology

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Endocrinology

Question
2 out of 10
 

Which of the pairs regarding vasopressin is incorrect: (AIIMS NOV.2010)


A v1- vascular smooth muscles

B v2-distal collecting ducts
C v3-anterior pituitary

D v4-CNS

Ans. D

There are three receptors of vasopressin: VH1A, VH1B( called VH3) & VH2

There is no V4 receptor of ADH.

Receptor

Gene

G protein

Functions

Arginine vasopressin receptor 1A

AVPR1A

Gq

Vasoconstriction

Arginine vasopressin receptor 1B
also called Arginine vasopressin receptor 3

AVPR1B

Gq

Neural

Arginine vasopressin receptor 2

AVPR2

Gs

Antidiuretic

Type

Second messenger system

Locations

Actions

AVPR1A

IP3/calcium

liver, kidney, peripheral vasculature, brain

vasoconstriction, gluconeogenesis, platelet aggregation, and release of factor VIII and von Willebrand factor

AVPR1B

IP3/calcium

pituitary gland, brain

ACTH secretion in response to stress

AVPR2

cAMP

basolateral membrane of the cells lining the collecting ducts of the kidneys

insert aquaporin-2 (AQP2) channels

Release of von Willebrand factor