54 out of 58
Which of these is an FDA approved indication for use of modafinil as an adjunct? (LQ)
|A||Major depression and associated lethargy|
|C||Obstructive sleep apnea|
|D||Shift work disorder|
Ans. B Narcolepsy
- Modafinil is a sympathomimetic drug and is alpha and beta agonist in brain. The drug also acts upon several other receptors. It has brain activating properties and is the drug of choice for narcolepsy.
- Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins. Orexin neurons are activated by modafinil. Orexinergic neurons are found exclusively in the lateral hypothalamic area.
- Their activation is associated with enhanced pleasure-seeking and motivation as well as arousal. Orexinergic fibers project to the entire central nervous system.
- Genetically modified orexin-knockout animals offer a model of human narcolepsy. Narcoleptics suffer profound disturbances in normal sleeping patterns and variable degrees of depression.
- These symptoms can be reversed with modafinil. Selective orexin receptor agonists of the future may prove useful both to narcoleptics and the population at large.