Medical and Surgical Complications in Pregnancy
Which one of the following perinatal infections has the highest risk of fetal infection in the 1st trimester? (DNB June 2013)
|D||Hepatitis B virus|
1. The most important factor in the pathogenicity of rubella virus for the fetus is gestational age at the time of infection. Maternal infection during the 1st trimester leads to fetal infection in about 50% of cases; maternal infection early in the 2nd trimester leads to fetal infection in about 1/3rd of cases.
2. Fetal malformations not only are more common after maternal infection in the 1 st trimester but also tend to be more severe and to involve more organ systems.