Which one of the following is the correct mechanism of action of CLOMIPHENE citrate? (LQ)
|A||Binds to estrogen receptors only|
|B||Blocking estrogenic inhibition of pituitary|
|C||Inhibit progesterone receptors|
- It bind to both ERA and ERB and acts as pure estrogen antagonist in all human tissues.
- It induces Gn secretion in women by blocking estrogenic feedback (estrogenic inhibition of pituitary).
- The amount of LH/FSH released at each secretory pulse is increased.
- In response the ovaries enlarge and ovulation occurs.
- Antagonism of peripheral actions of estrogen results in hot flushes endometrium and cervical mucus modified.
- Clomiphene or clomiphene is a selective estrogen receptor modulator (SERM).
i. The chief use of clomiphene is in sterility due to failure of ovulation.
ii. To aid in vitro fertilization.
iii. Oligozoospermia: In men also clomiphene increases Gn secretion promotes spermatogenesis and testosterone secretion.
· Polycystic Ovaries
· Multiple Pregnancies
· Hot Flushes, Gastric Upset
· Allergic Dermatitis
· Risk Of Ovarian Tumor May Be Increase.