Which one of the following is the correct mechanism of action of CLOMIPHENE citrate?
|A||Binds to estrogen receptors only|
|B||Blocking estrogenic inhibition of pituitary|
|C||Inhibit progesterone receptors|
a. It bind to both ERA and ERB and acts as pure estrogen antagonist in all human tissues.
b. It induces Gn secretion in women by blocking estrogenic feedback (estrogenic inhibition of pituitary).
c. The amount of LH/FSH released at each secretory pulse is increaseD.
d. In response the ovaries enlarge and ovulation occurs.
e. Antagonism of peripheral actions of estrogen results in hot flushes endometrium and cervical mucus modifieD.
f. Clomifene or clomiphene is a selective estrogen receptor modulator (SERM).
a. The chief use of clomiphene is in sterility due to failure of ovulation.
b. To aid in vitro fertilization.
c. Oligozoospermia: In men also clomiphene increases Gn secretion promotes spermatogenesis and testosterone secretion.
• Polycystic ovaries, multiple pregnancies, hot flushes, gastric upset, vertigo and allergic dermatitis. Risk of ovarian tumor may be increase.