Which one of the following drugs increases gastrointestinal motility? (LQ)
Anticholinesterase drugs increase the level of ACh by protecting it from hydrolysis.
Neostigmine is an anticholinesterase drug, it protect acetylcholine which acts on different systems as follows:
Actions of acetylcholine on smooth muscle
Evacuation of bowel
Constriction (Asthmatic highly sensitivity)
Precipitation of bronchial asthma
↑ Peristalsis of ureter
Detrusor muscle contraction
Sphincter and trigone relaxation
↓ Voiding of bladder
a. It is an opioid analgesic which leads to constipation by:
b. Direct action on GIT/CNS increases tone and segmentation but decreases propulsive movement.
c. Spasm of pyloric / ileo-caecal and anal sphincters.
d. Decrease in all GIT secretions.
e. Increased due to stasis absorption of water.
f. Central action causing inattention to defecation reflex.
a. Anticholinergic drug
b. Potent anti secretory
c. Potent antibradycardia drug
d. Lack of central action
e. Used in preanesthetic medication