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Pharmacology

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GIT

Question
8 out of 53
 

Which one of the following drugs increases gastrointestinal motility? (LQ)



A Glycopyrrolate
B Atropine

C Neostigmine
D Fentanyl

Ans. C Neostigmine

Anticholinesterase drugs increase the level of ACh by protecting it from hydrolysis.

Neostigmine is an anticholinesterase drug, it protect acetylcholine which acts on different systems as follows:

Actions of acetylcholine on smooth muscle

GIT

Bronchial muscle

Genito-urinary tract

tone

Peristalsis

Sphincters relaxation

Abdominal cramps

Evacuation of bowel

Constriction (Asthmatic highly sensitivity)

Dyspnea

Precipitation of bronchial asthma

Peristalsis of ureter

Detrusor muscle contraction

Sphincter and trigone relaxation

Voiding of bladder

Fentanyl:

a. It is an opioid analgesic which leads to constipation by:

b. Direct action on GIT/CNS increases tone and segmentation but decreases propulsive movement.

c. Spasm of pyloric / ileo-caecal and anal sphincters.

d. Decrease in all GIT secretions.

e. Increased due to stasis absorption of water.

f. Central action causing inattention to defecation reflex.

Glycopyrrolate :

a. Anticholinergic drug

b. Potent anti secretory

c. Potent antibradycardia drug

d. Lack of central action

e. Used in preanesthetic medication

GIT Flashcard List

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