Which one of the following histologic findings from a blood vessel would be most consistent with a diagnosis of Buerger’s disease? (AIIMS May 2013)
|A||Granulomatous inflammation with giant cells|
|B||Fibrinoid necrosis with overlying thrombosis|
|C||Focal aneurysmal dilation|
|D||Thrombosis with microabscesses|
a. Almost always occurs in cigarette smokers at a young age (usually below 35 years) and is often associated with HLA-A9,B5 genotypes.
b. The vessels primarily affected are in the extremities, and this leads to painful ischemia and gangrene of the legs and arms due to thrombosis.
c. Histologic sections reveal an acute inflammatory infiltrate involving the entire wall of the vessel. In contrast to atherosclerosis, small microabscesses may be seen within thrombi.