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Biochemistry

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Vitamins, Harmones and Hemoglobin

Question
10 out of 30
 

Which one of the following statements concerning the hemoglobins is correct?



A Fetal blood has a higher affinity for oxygen than does adult blood because Hb F has a decreased affinity for 2,3-BPG.

B Purified Hb F (stripped of 2,3-BPG) has a higher affinity for oxygen than does purified Hb A.

C The chain composition of Hb F is α2δ2.

D Hb A1c differs from Hb A by a single, genetically determined amino acid substitution.

Ans. A Fetal blood has a higher affinity for oxygen than does adult blood because Hb F has a decreased affinity for 2,3-BPG.

a. Because 2,3-BPG reduces the affinity of hemoglobin for oxygen, the weaker interaction between 2,3-BPG and Hb F results in a higher oxygen affinity for Hb F relative to Hb A. In contrast, if both Hb A and Hb F are stripped of 2,3-BPG, they have a similar affinity for oxygen. Hb F consists of α2γ2.

b. Hb A1c is a glycosylated form of Hb A, formed nonenzymically in red cells. Hb A2 is a minor component of normal adult hemoglobin, first appearing about twelve weeks after birth.

Vitamins, Harmones and Hemoglobin Flashcard List

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