Which statement regarding transmission of viral illness through homologous blood transfusion is true?
|A||The most common viral agent transmitted via blood transfusion is HIV|
|B||Blood is routinely tested for CMV because CMV infection is often fatal|
|C||The most frequent infectious complication of blood transfusion continues to be viral meningitis|
|D||Up to 10% of those who develop posttransfusion hepatitis will develop cirrhosis or hepatoma or both.|
a. Transmission of the infectious agents for hepatitis is among the most serious risks associated with blood transfusion.
b. Transfusion-associated HBV infection occurs in approximately 1 in 30,000 to 250,000 units transfused. The risk of transmitting HCV is now as low as 1 in 1 million.
c. Symptoms develop in approximately half the blood recipients who contract HBV infection. In approximately half the patients who contract post-transfusion HCV infection, a chronic form of the disease develops.
Human Immunodeficiency Virus
The the risk of HIV transmission is estimated to be as low as 1 in 2 million units.
Human T-Cell Leukemia Virus
a. Transmission of the virus, especially to immunocompromised patients, may cause illnesses such as T-cell leukemia, spastic paraparesis, and myelopathy.
b. The risk of HTLV-I and HTLV-II transmission is estimated to be 1 in 641,000 units.
b. About 20% of blood donors are infected with CMV by 20 years of age, and approximately 70% are infected by the age of 70
c. Human herpesvirus 8 causes Kaposi's sarcoma and lymphoma in patients with acquired immunodeficiency syndrome and other immunosuppressed states such as transplantation.