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Medicine

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Kidney

Question
6 out of 11
 

Wire loop lesions are often characteristic for the following class of lupus nephritis: (AIPG 02)



A Mesangial proliferative glomerulonephritis

(WHO class II)

B Focal proliferative glomerulonephritis (WHO class III)

C Diffuse proliferative glomerulonephritis (WHO class IV)

D Membranous glomerulonephritis (WHO class V)

Ans. C Diffuse proliferative glomerulonephritis (WHO class IV)

Renal involvement in SLE

Table: Classification for Lupus Nephritis (Ref. H-18th Edi, P- 2341 Table 283-3)

Class I

Minimal mesangial

Normal histology with mesangial deposits

Class II

Mesangial proliferation

Mesangialhypercellularity with expansion of the mesangial matrix

Class III

Focal nephritis

Focal endocapillary ± extracapillary proliferation with focal subendothelial immune deposits and mild mesangial expansion

Class IV

Diffuse nephritis

Diffuse endocapillary ± extracapillary proliferation with diffuse subendothelial immune deposits and mesangial alterations (Diffuse wire loop deposits)

Class V

Membranous nephritis

Thickened basement membranes with diffuse subepithelial immune deposits; may occur with Class III or IV lesions and is sometimes called mixed membranous and proliferative nephritis

Class VI

Sclerotic nephritis

Global sclerosis of nearly all glomerular capillaries

(Extra Edge: In SLE, wire loop deposits is seen in diffuse nephritis )

Kidney Flashcard List

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