Female Genital Tract
With regard to the malignant behavior of leiomyosarcoma, the most important criterion is: (LQ)
|A||Blood vessel penetration by tumor cells|
|B||Tumor cells in lymphatic channels|
|D||The number of mitoses per high power field|
• The most important criterion for distinction of leiomyosarcoma from leiomyoma (malignant transformation) is the number of mitoses Present.
• Ten high power fields (hpf) are examined. If > 10 mitoses are seen it signifies malignancy lf cellular atypia is also present >5 mitoses are enough to make a diagnosis of leiomyosarcoma.