Wound healing by secondary intention is characterised by?
|B||Thick collagenous scar|
|D||Soft line scar|
a. Wound contraction occurs by centripetal movement of the whole thickness of the surrounding skin and reduces the amount of disorganized scar.
b. Wound contracture, in contrast, is a physical constriction or limitation of function and is a result of the process of wound contraction. Contractures occur when excessive scar exceeds normal wound contraction, and it results in a functional disability
c. Fibroblasts in a contracting wound undergo change to stimulated cells, referred to as myofibroblasts. These cells have both function and structure in common with fibroblasts and smooth muscle cells and express alpha smooth muscle actin in bundles called stress fibers. The actin appears at day 6 after wounding, persists at high levels for 15 days, and is gone by 4 weeks when the cell undergoes apoptosis.
d. Stimulated fibroblasts, or myofibroblasts, are found to be a constant feature present in abundance in diseases involving excessive fibrosis. Such diseases include hepatic cirrhosis, renal and pulmonary fibrosis, Dupuytren's contracture, and desmoplastic reactions induced by neoplasia.