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Microbiology

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RNA Viruses

Question
86 out of 94
 

You isolate a virus from the stool of a 1-year-old infant with signs of fever, vomiting, and diarrhea. Laboratory results show that the viral genome is composed of multiple segments of double-stranded RNA, which leads you to suspect that rotavirus is the causative agent of infection. Which of the following statements is true regarding rotavirus replication?(AIPG 2009)



A The viral genome integrates into the host chromosome.

B The virus uses the host RNA polymerase for replication of its genome.

C The segmented genome contributes to the antigenic variation of the virus.

D The viral agent has a single antigenic type.

Ans. C The segmented genome contributes to the antigenic variation of the virus.

a. The segmented genome of Rotaviruses, allows for the assembly of new virions with mixed genomes in cells multiply infected as a result of reassortment; answers A, B, D are incorrect:

b. The rotaviral genome consists of double-stranded RNA and replicates in the cytoplasm and thus does not integrate into the host chromosome;

c. As an RNA virus that replicates in the cytoplasm, the rotoviral genome is replicated by a viral RNA polymerase;

d. The high genetic variability of rotaviruses because of reassortment results in multiple viral serotypes, at least nine different serotypes have currently been classified in human illness; (E) newly assembled nonenveloped rotaviral particles are released by cell lysis.

RNA Viruses Flashcard List

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