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Pathology

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Miscellaneous

Question
27 out of 28
 

classic destructive joint lesion found in individuals with rheumatoid arthritis. is known as (AIIMS Nov 2012)



A Eburnation
B Gumma

C Pannus
D Spondylosis

Ans. C Pannus

a. Pannus is the name given to describe the classic destructive joint lesion found in individuals with rheumatoid arthritis.

b. This lesion is characterized by proliferation of the (hyperplasia) along with numerous chronic inflammatory cells.

c. The thickened synovial membrane may develop villous projections, which can destroy the joint cartilage.

d. Nodular collections of lymphocytes resembling follicles are characteristically seen along with numerous plasma cells.

e. Palisades of proliferating cells may surround areas of necrosis.

f. This latter histologic appearance can be seen in subcutaneous nodules (rheumatoid nodules), but rheumatoid arthritis most frequently affects the small joints of the hands and feet.

g. Larger joints are involved later. In contrast to a pannus, gummas are seen with syphilis, while tophi are found with gout.

h. Finally, eburnation describes the “polished” appearance of the bone affected by degenerative joint disease, while spondylosis refers to a degenerative process of the vertebrae that can compress the spinal cord and its nerve roots.

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