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Pathology

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Miscellaneous

Question
28 out of 28
 

osteomalacia is due to ? (AIPG 2011)



A Failure of bone remodeling

B Failure of bone mineralization

C Failure of osteoid formation

D Reactive bone formation

Ans. B Failure of bone mineralization

Osteomalacia (soft bones) is a disorder of adults characterized by inadequate mineralization of newly formed bone matrix and is most often associated with abnormalities of vitamin D metabolism (such as dietary deficiency or intestinal malabsorption of vitamin D), hypoparathyroidism, or chronic renal diseases. Rickets is a similar condition that occurs in children. Defective mineralization results in an increase in the thickness of the osteoid seams.

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