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Medicine

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Hematology

Question
7 out of 10
 

t (2- 8) is associated with (AIPG 2010)



A CML
B AML

C T cell ALL
D Burkitt lymphoma

Ans. D

Burkitt lymphoma

Burkitt lymphoma is a cancer of the lymphatic system (in particular, B lymphocytes).

Genetics

Burkitt's lymphoma is associated with c-myc gene translocation. This gene is found at 8q24.

1. The most common variant is t(8;14)(q24;q32). This involves c-myc and IGH@.

2. A rare variant is at t(2;8)(p12;q24). This involves IGK@ and c-myc.

3. Another rare variant is t(8;22)(q24;q11). This involves IGL@ and c-myc.

Malignant B cell characteristics

1. Normal B cells possess rearranged immunoglobulin heavy and light chain genes and each isolated B-cell possesses a unique IgH gene rearrangement.

2. Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are supposed to possess identical IgH genes.

3. When the DNA of tumor cells is analyzed using electrophoresis, a clonal band can be demonstrated since identical IgH genes will move to the same position.

Treatment: Chemotherapy

1. Cyclophosphamide

2. Doxorubicin

3. Vincristine

4. Methotrexate

5. Cytarabine

6. Ifosfamide

7. Etoposide

8. Rituximab

Other treatments are immunotherapy, bone marrow transplants, surgery to remove the tumor, and radiotherapy.

Hematology Flashcard List

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