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Biological Sciences

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Transcription and Translation

Question
5 out of 7
 

Which of the following mRNA sequences encode the same protein?

I. 5’ UUAAGAUCC 3’

II. 5’ UUGCGUUCU 3’

III. 5’ CUGCGGAGU 3’



A I and II
B II and III
C I and III
D I, II and III
Ans. D

Using the genetic code in Figure 6.3, all of the mRNA sequences can be found to code for the same amino acid sequence.

Transcription and Translation Flashcard List

7 flashcards
1)
2)
A newly discovered genetic disease has been observed in several large families. Characteristics of the disease include mental retardation and coronary defects. Researchers studying this disease have isolated the responsible gene. The functional protein encoded by this gene consists of a single polypeptide chain. Experiments were done to determine the exact sequence of the gene with the following results: Sequencing result 1: In a family with no history of the disease, the gene was found to be 849 nucleotides long, encoding a protein containing 283 amino acids. The mRNA sequence coding for the 22-26th amino acids is shown below: 5’ AUUCCUAGUUGCACG 3’ Sequencing result 2: The genetic disease runs in family A. However, in this family, the disease is not severe and most affected individuals lead a fairly normal life. The mRNA transcribed form this gene is shown below (corresponding to the same region of the normal gene in result 1): 5’ AUUCCUAGAUGCACG 3’ Sequencing result 3: The disease is also present in family B, but affected individuals are much worse off than those in family A. The gene was sequenced, and the corresponding mRNA is shown below (same region as sequence results 1 and 2): 5’ AUUCCUAGUUGAACG 3’ The mutation in family A (sequencing result 2) will cause which of the following results?A A protein will not be made.B There will be a single amino acid change in the protein.C The heart in an individual with the mutation will not develop correctly.D There will be a change in the quaternary structure of the protein.
3)
A newly discovered genetic disease has been observed in several large families. Characteristics of the disease include mental retardation and coronary defects. Researchers studying this disease have isolated the responsible gene. The functional protein encoded by this gene consists of a single polypeptide chain. Experiments were done to determine the exact sequence of the gene with the following results: Sequencing result 1: In a family with no history of the disease, the gene was found to be 849 nucleotides long, encoding a protein containing 283 amino acids. The mRNA sequence coding for the 22-26th amino acids is shown below: 5’ AUUCCUAGUUGCACG 3’ Sequencing result 2: The genetic disease runs in family A. However, in this family, the disease is not severe and most affected individuals lead a fairly normal life. The mRNA transcribed form this gene is shown below (corresponding to the same region of the normal gene in result 1): 5’ AUUCCUAGAUGCACG 3’ Sequencing result 3: The disease is also present in family B, but affected individuals are much worse off than those in family A. The gene was sequenced, and the corresponding mRNA is shown below (same region as sequence results 1 and 2): 5’ AUUCCUAGUUGAACG 3’ The disease in family B (sequencing result 3) is probably more severe than in family A because:A There is a slight but significant change in the amino acid sequence.B A frame shift mutation caused the amino acid sequence of the protein to be incorrect from the point of mutation on.C A termination codon caused the truncation of the protein, preventing it from functioning.D A point mutation altered a critical amino acid.
4)
A newly discovered genetic disease has been observed in several large families. Characteristics of the disease include mental retardation and coronary defects. Researchers studying this disease have isolated the responsible gene. The functional protein encoded by this gene consists of a single polypeptide chain. Experiments were done to determine the exact sequence of the gene with the following results: Sequencing result 1: In a family with no history of the disease, the gene was found to be 849 nucleotides long, encoding a protein containing 283 amino acids. The mRNA sequence coding for the 22-26th amino acids is shown below: 5’ AUUCCUAGUUGCACG 3’ Sequencing result 2: The genetic disease runs in family A. However, in this family, the disease is not severe and most affected individuals lead a fairly normal life. The mRNA transcribed form this gene is shown below (corresponding to the same region of the normal gene in result 1): 5’ AUUCCUAGAUGCACG 3’ Sequencing result 3: The disease is also present in family B, but affected individuals are much worse off than those in family A. The gene was sequenced, and the corresponding mRNA is shown below (same region as sequence results 1 and 2): 5’ AUUCCUAGUUGAACG 3’ An in vitro transcription/translation system was set up to express the isolated genes. Which alteration in the system would allow the gene from family A to be translated into a fully functional protein?A Include a ribosome that would not recognize the codon AGAB Use a tRNA with the anticodon UCU that carries the amino acid serineC Replace the normal splicing machinery with one that will remove the incorrect codonD Substitute the normal RNA polymerase with one that randomly makes mistakes to correct the mutation
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