'Hurthle cells' are seen in (LQ)
|C||Papillary carcinoma of the thyroid|
Hashimoto’s thyroiditis (Chronic lymphocytic thyroiditis)
1). Most common auto immune cause of goitrous hypothyroidism. It is painless.
2). 20-60 yrs old women
3). Histology: Hurthle cells (cells with intensely eosinophilic, granular cytoplasm) are seen, diffuse parenchymal infiltration by lymphocytes.
4). Anti-thyroglobulin antibody and Thyroid peroxidase antibodies are present in the serum.
5). Antinuclear factor (ANF) may be positive.
6). Thyroxine therapy
7). May be associated with other autoimmune diseases (SLE, RA, SS [Sjogren's syndrome], etc.)
8). Complication: increased risk of non-Hodgkin‘ lymphoma (NHL) B cell lymphoma
Extra Edge: In Papillary carcinoma of the thyroid the macroscopic appearance of a papillary carcinoma with grossly discernible papillary structures is notable. The well-formed papillae, lined by cells with characteristic empty-appearing nuclei, sometimes termed "Orphan Annie eye" nuclei are characteristic. Cells obtained by fine-needle aspiration of a papillary carcinoma may characteristically show intranuclear inclusions.