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Hallucinogens: lysergic acid (LSD)​

Presumably produces its effects by an action on the 5-HT levels in Brain Common pattern of LSD use is a trip (Occasional use followed by a long period of abstinence. no physical or psychological dependence, common in rave parties, sometimes acute LSD Intoxication presents with acute panic attack ( “ BAD TRIP ” ) flashbacks are common.
These are agents producing intense perceptual disturbances. Natural agents in this group are psilocybin, mescaline, harmine, harmaline, Ibogaine, and dimethyltryptamine (DMT). The classic synthetic hallucinogen is Lysergic acid diethylamide (LSD). LSD, considered as the "king of psychedelic", is the most powerful hallucinogen known to man.
LSD intoxication
  • LSD produces its effect by action an serotonin (5-HT) levels in brain. It produces: -
  1. Perceptual disturbances in a clear consciousness: - Depersonalization, derealization, intensification of  perceptions (colour looks more bright), Synesthesia (colors are heard, sounds are felt), illusions, and hallucination.
  2. Autonomic hyperactivity (due to central sympathetic stimulation) : - Tachycardia, sweating, tremors, mydriasis, incoordination, increased temperature, piloerection.
  3. Anxiety, panic, Increased tendon reflexes, depression, Persecution & referential ideation, and confusion.
Treatment of choice for hallucinogen intoxication is diazepam. Neuroleptics (e.g., phenothiazines) may have psychomimetics effects and thus are not indicated in patients with LSD intoxication.

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