'Weak giants'are produced by - (AIIMS Nov 2014)
Pituitary adenoma [Ref Harrison 16b/e p. 2090; Nelson lP/e p. 2303, 23041
o In children and adolescent growth hormone hypersecretion prior to epiphyseal long bone closure causes gigantism.
o The muscles often appear enlarged but the1, have decreased force generation.
o So, hyperpituitarism causes giants which have weak muscles and the most common cause of hyperpituitarism is pituitary adenoma.
o Myopathy of hyperpituitarism -
• Patients with hyperpituitarism hate mild proximal weakness with muscle atrophy.
• Myopathy is related to the degreed of acromegaly.
o Remember that all endocrinal disorders cause myopathy but none of them cause gigantism except hyperpituitarism.