A highly ionized drug: (DNB Dec 2009)
|A||Is excreted mainly by the kidney|
|B||Can cross the placenta easily|
|C||Is well absorbed from the intestine|
|D||Accumulates in the lipids|
A highly ionized drug is not reabsorbed by the tubules and is easily excreted by the kidneys because it is lipid insoluble.
Ionization increases renal clearance of drugs:
- Only free, unbound drug is filtered
- Both ionized and non ionized forms of a drug are filtered.
- Only non ionized forms undergo active secretion and active or passive 'reabsorption.
- Ionized forms of drug are "trapped" in the filtrate.
Non ionized drugs