Amino Acids, Proteins and Porphyrins
A peptide bond:
|A||Has a partial double-bond character.|
|B||Is ionized at physiologic pH.|
|C||Is cleaved by agents that denature proteins, such as organic solvents and high concentrations of urea.|
|D||Is stable to heating in strong acids.|
|E||Occurs most commonly in the cis configuration.|
a. The peptide bond has a partial double-bond character. Unlike its components—the α-amino and α-carboxyl groups—the components of the peptide bond do not accept or give off protons.
b. The peptide bond is not cleaved by organic solvents or urea, but is labile to strong acids. It is usually in the trans configuration.