Liver & Gall Bladder
A young woman Ms Shaano who is otherwise normal goes for an annual examination in a nursing home. Her blood investigations reveal hemoglobin is 15 g*/ dl, TLC is 7,000/mm3, ESR is L2mmlhr. Her kidney and liver function tests are also normal. She undergoes a radiological scanning too. Dr. Sethi, the radiologist describes her findings to be normal except a mass in the right lobe of the liver. A biopsy is taken which confirms the diagnosis of a liver adenoma. Which of the following is likely to be associated with this lesion? (AIIMS Nov 2013)
Liver adenomas are benign liver tumors commonly associated with oral contraceptive use in young women (usually 3-4th decade of life). They may resemble hepatocellular carcinoma. If they are subscapular, they can rupture, causing intraabdominal haemorrhage leading to acute abdominal pain.
Hepatitis B may lead to hepatocellular carcinoma.
Polycythemia vera is associate with thrombosis of the hepatic venis.
Polyvinyl chloride, thorotrast (a contrast material) and arsenic are the risk factors for development of angiosarcoma of the liver, Immunohistochemical staining of these tumor cells is positive for the CD 31 cell marker.