ACE inhibitors which of the following is true?
|A||Inhibit angiotensinogen conversion to angiotension-I|
|B||Omit diuretics to prevent 1st dose hypotension|
|C||Enalapril is more long acting than lisinopril|
|D||Can’t given till systolic dysfunction resolve|
a. ACEI inhibit the conversion of AT – I to AT – II.
The drugs which prevent conversion of Angiotensinogen to AT- I are direct renin inhibitors like aliskiren and remikiren. (OPTION A.)
b. 1st dose hypotension is a one of the side effect of ACEI seen; they being powerful arteriolar dilators.
It is commonly seen in patients suffering from CHF & those, which are on vigorous diuretic therapy. Thus to avoid this effect; diuretics should be omitted. (OPTION B).
c. Enalapril is shorter acting than lisinopril; though both can be given OD. The duration of action of enalapril is 24 hrs while that for lisinopril is more than 24 hrs. The elimination half-life is 11 & 12 hrs respectively. (OPTION C.)
d. They are indeed, one of the first drugs to be given in systolic dysfunction. (OPTION D).
ACE inhibitors are the drug of choice:
· Diabetes with hypertension
· Nephropathy wit hypertension
· Reno-vascular hypertension
· Unilateral renal artery stenosis
These drug improve left ventricular dysfunction hence are the front like drugs in CHF