Acid secretion is not increased by:
|C||Food in stomach|
I. Acid secretion is stimulated by GASTRIN and by postganglionic VAGAL FIBERS via muscarinic cholinergic receptors on parietal cells.
II. The major physiologic stimulus for gastric acid secretion is INGESTION OF FOOD.
III. Gastrin is the most known stimulant of gastric acid secretion.
IV. Gastrin release is stimulated by a neuropeptide gastrin-releasing peptide and inhibited by somatostatin produced by D cells in the antrum. SOMATOSTATIN REDUCES GASTRIC ACID SECRETION by inhibiting gastrin release, by directly inhibiting parietal cell secretion, and by inhibiting the release of histamine.