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6 out of 8

Addison's disease is characterized by following except: (NEET 2014)

A Hyperkalemia
B Hypotension

C Hyponatremia
D Hypocalcemia

Ans. D



1). Fatigue, weakness, anorexia, weight loss

2). Dizziness, fainting, Asthenia is most common symptoms (MCQ)

3). Myalgia, arthralgia.

4). Mood: depression, psychosis, low self-esteem. Enhancement of the sensory modalities of taste, olfaction, and hearing is reversible with therapy.

5). GI: nausea or vomiting, abdominal pain, diarrhea or constipation. Note: Both diarrhea or constipation can occur (Ref. Hari - 18th ed., table 336-7, Pg. 2263)

Note: Due to low BP & hypoglycemia, the commonest symptom of Addison’s disease is Asthenia.

Clinical Feature of addisonian crises.

1). Intractable vomiting

2). Acute pain abdomen

3). Hypotension

4). COMA and death


1). Hypotension

2). Postural hypotension. (MCQ)

3). Vitiligo may be associated.

4). Signs of critical deterioration: Shock (BP, tachycardia), fever, coma, cardiac atrophy

5). Hyper pigmentation due to increase ACTH which is a precursor of MSH. But Vitiligo may be associated.

Extra Edge: The increased MSH in Addison's causes melanocytes to disperse melanin in the epidermis thus increasing pigmentation.