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5 out of 6

All are true for growth factor receptors except:(LQ)

A RET – proto-oncogene is normally expressed in neuroendocrine cells

B MEN 2A is associated with point mutation in extracellular domain

C MEN 2B is associated with point mutation with intracellular domain

D ERBB-1 is associated breast cancer

Ans. D ERBB 2/ HER2-neu is associated with breast cancer and ovarian cancers. ERBB 1 is associated with SCC lung, gliomas, and head and neck tumors.