All of the following are true regarding angiotensin converting enzyme (ACE) inhibitors except
|A||Increase proteinuria in renal disease|
|B||Inhibits conversion of angiotensin I to angiotensin II|
|C||Decreases peripheral resistance|
Captopril induced hypotension is a result of decrease in total peripheral resistance as a result of decreased production of angiotensin-II. ACE inhibitors cause both arterial and veno dilatation of patients of CHF; reduce afterload as well as preload. Exact mechanism of antihypertensive action of ACI; inhibitors is unknown but is thought to be related to competitive inhibition of angiotensin converting enzyme (ACE) activity, resulting in a decreased rate of conversion of angiotensin Ito angiotensin into, which is a potent vasoconstrictor.
· Proteinuria occurs in about 1 % of patients.