All of the following are true about vancomycin; except: (AIIME Nov 2010)
|A||Glycopeptide with bactericidal action|
|B||Can cause pseudomembranous colitis|
|C||Inhibits protein synthesis|
|D||Inhibits mRNA transfer|
Vancomycin is bactericidal for most organisms; bacteriostatic for enterococci; inhibits bacterial cell wall synthesis at a site different from that of penicillins and cephalosporins by binding tightly to D-alanyl-D-alanine portion of cell wall precursor; this leads to destruction of bacterial cell by lysis.
a. Vancomycin may also alter permeability of bacterial cytoplasmic membranes and may selectively inhibit ribonucleic acid (RNA) synthesis; also active against 'L' forms because of its intracellular action; does not compete with penicillins for binding sites.
b. Given orally (a route by which it is not absorbed), vancomycin can be used to treat antibiotic-associated pseudomembranous colitis caused by C. difficile in patients who have failed to respond to metronidazole, the drug of choice.