All the following are features of progesterone pills EXCEPT
|A||Involves cervical mucous|
|B||Breaks ovulation cycle|
|D||Contraindicated in breast cancer|
a. Progesterone pills - mechanism of action
i. Uterus - Progesterone brings about secretary changes in the estrogen primed endometrium: hyperemia, tortuosity of glands and increased secretion occurs while epithelial proliferation is suppressed.
ii. Cervix - Progesterone converts the watery cervical secretion induced by estrogens to viscid, scanty and cellular secretion which is hostile to sperm penetration,
iii. Vagina - progesterone induces pregnancy like changes in vaginal mucosa –leukocyte infiltration of cornified epithelium
b. Progesterone carrying devices causes alteration in the cervical mucus which prevents penetration of sperms.
c. Contraindication - Previous ectopic pregnancy, ovarian cyst, breast and genital cancers, abnormal vaginal bleed, active liver, and arterial disease, porphyria
d. Uses - contraceptive, HRT, DVB, Endometriosis, endometrial carcinoma, premenstrual tension, threatened / habitual abortion.