As part of the management of a 28-year-old male with acute onset of Crohn’s disease of the small bowel, you decide to treat him with a new cocktail of mouse-human chimeric antibodies to reduce his intestinal inflammation and cachexia. To what set of proteins may these antibodies be directed?
|A||IL-1, IL-2, IL-3|
|B||IL:-2, IL-12, TNF|
|C||IL-2, TGF-, TNF-|
|D||IL-1, IL-6, TNF|
The acute – phase response is a primitive, nonspecific defense reaction, mediated by the liver, that increases innate immunity and other protective functions in stressful times.
It can be triggered by chronic auto- immune disorders such as rheumatoid arthritis and Crohn’s disease.
This response occurs when hepatocytes are exposed to IL-6 and IL-1 of TNF-alpha.
LPS is a potent inducer of these cytokines. They are responsible for fever, somnolence, loss of appetite, and, if the response is prolonged, anemia and cachexia (wasting).