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A. Site of production of lymphocytes after birth

  1. Some lymphocytes are formed in the bone marrow.
  2. However, most are formed in the lymph nodes, thymus, and spleen. The precursor cells are originally from the bone marrow; these precursor cells then get processed either in the thymus or bursal equivalent. These processed precursor cells move to the lymph nodes, thymus and spleen.

B. Release into the circulation

From their site of production, the lymphocytes enter the blood­stream mostly via the lymphatics. At any given time, only about 2% of the body lymphocytes are in the peripheral blood. Most of the rest are in the lymphoid organs. Approximately, 3.5 x 1010 lymphocytes per day enter the circulation via the thoracic duct alone; however, this count includes cells that reenter the 1ymphatics and thus traverse the thoracic duct more than once.


C.  Function

Lymphocytes play a very important role in im­munity.

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