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Bone Metastasis

  1. It is most common bone tumor( 95 % of bone tumors are secondary and only 5% is primary)
  2. Most common source primary source is breast carcinoma followed by prostate carcinoma
  3. Most common site is spine(dorsal spine)
  4. Most common pathological fracture is hip fracture (trochanteric region)
  5. Only 20 % of metastatic bone tumors are symptomatic
  6. Lytic and expansile lesions: secondaries from lung, thyroid, renal
  7. Blastic (sclerotic): CA prostate -90% of cases, CA breast – 60 % of cases
  8. Below knee and elbow lesion are rare but can be seen in CA bronchus, bladder, colon.


  1. Purely Osteolytic
    1. Kidney (expansile)
  2. Mostly Osteolytic
    1. Thyroid
    2. Breast (may be mixed)
    3. Grastro intestinal tract
  3. Mostly Osteoblastic
    1. Seminoma
    2. Neurogenic tumors
    3. Uterus
    4. Ovary
    5. Urinary bladder
  4. Purely Osteoblastic
    1. Prostate
    2. Carcinoid
  1. Neuroblastoma (adrenal), osteosarcoma and Ewings sarcoma are pediatric malignancies commonly metastasizing to bone.
  2. Sarcomas of soft tissue origin do not as frequently involve bone.
  3. Rhabdomyosarcoma is the most common soft tissue tumor in child.
  4. Malignant fibrous histocytoma is the most common soft tissue tumor in adult

Sarcomas metastasizing through lymphatic and causing lymph node involvement are:


S - Synovial cell sarcoma


A - Angiosarcoma


M - Malignant fibrous histocytoma


E - Epithelial sarcoma


C - Clear cell sarcoma


L - Lymphosarcoma


R - Rhabdomyosarcoma

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