Autocoids (Histamine and Serotonin)
COX 2 is implicated in (AIIMS Nov 2009)
COX-2 has been implicated in tumor metastasis. It enhances u2 P1 integrin expression and cell migration via EP1 dependent signaling pathway. COX-2 is also involved in inhibition of cell apoptosis, augmentation of angiogenesis as well as increased cell motility.