Autonomic Nervous Systems
Carisoprodol activation forms which metabolite:
a. Carisiprodol is a rapidly acting and is a centrally acting muscle relaxant.
b. The drug blocks the electrical communication among the central nerves in brain.
c. The drug starts acting with in 20 minutes and the effects last for 2-6 hours.
d. It is metabolized quickly by cytochromal enzymes to maprobamate, which is an independent muscle relaxant.
e. However, maprobamate has abuse potential. Usual dose of carisiprodol is 350 mg daily and sedation is main side effect.
f. Carisiprodol is believed to have less abuse potential.
g. Maprobamate was used in the past as a selective anti-anxiety drug with insomnia.
h. However, now a days, benzodiazepines are the drugs of choice for this condition.
i. Presently, though, carisiprodol type of drugs are used orally sometimes in orthopaedic conditions; they are often given in combination with NSAIDs as topical formulations for back pain, sprains, lumbago etc.