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Meissener’s Corpuscles:  Tactile Receptors

  • Encapsulated endings
  • Ellipsoidal structure
  • Occur in groups
  • Found on: Skin of finger tips, Lips, nipples, Orifices of body


Pacinian Corpuscles

Quickly adapting receptors responds to deformity caused by firm pressure
Encapsulated & spherica
Located in:   Subcutaneous tissue: Pressure
Neighbourhood of tendons & joints: Vibrations

End Bulb Of Krause: Mechanoreceptors

  1. Encapsulated & spherical
  2. Found in: Papillae of lips, tongue, skin of genetalia, in sheaths of nerves.
  3. FIBRE: A-GROUP (δ)

Organ of Ruffini

  1. Mechanorecetors/degree of warmth, cold
  2. Expanded ends of sensory nerve fibres
  3. Slowly adapting touch receptors
  4. Found in dermis
  5. Nerve fibre type associated with these receptors are A δ Type or C

Merkels Disc: Tactile Receptors

  1. Expanded tips
  2. Grouped together in a single receptor organ – Iggo Dome receptor
  3. Under epithelium of skin

Free Nerve Endings [Uncapsulated]

  1. Responds to noxious stimuli- pain
  2. Also responds to touch & temperature
  3. Fibre:  terminal branches of thin myelinated A δ(Fast pain) & unmyelinated C fibres(slow pain)

Transient receptor potential (TRP) ion channel: The TRP channels are a family of 6 transmembrane spanning domain proteins expressed in low numbers per cell to yield small net inward currents. Humans use TRP channels to appreciate sweet, bitter and umami (amino acid) tastes, and to discriminate warmth, heat and cold. The TRPV (use pepper derived vanilloid compound capsaicin as a ligand) subfamily involved in neuronal pain pathways, sense heat and osmolarity. The TRPM (long TRPC, Melastatin) subfamily involved in Ca2+ dependent signaling, control of cell cycle progression, division or migration, and thermosensation.

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