Cilastatin is added to imipenem because it:
|A||Inhibits the liver enzymes resulting in decreasing of its metabolism|
|B||Prevents development of resistance by acting on beta-lactamases|
|C||Decreases the metabolism of imipenem in the kidneys|
|D||Prevents the adverse effects of imipenem|
a. Imipenem is a new extremely potent and most broad-spectrum beta-lactam antibiotic. It is resistant to most beta lactamases and inhibits penicillinase-producing staphylococci.
b. A 'limiting feature' of imipenem is its rapid hydrolysis by the enzyme dehydropeptidase I located on the brush border of renal tubular cells.
c. An innovative solution to this problems its combination with cilastatin, a reversible inhibitor of dehydropeptidase, which has matched pharmacokinetics with imipenem and protects it.