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Male Antifertility Method Under Research

Gossypol: The Chinese male pill Gossypol has been used in China since 1972 and is still used there. It is disequiterpene aldehyde. Gossypol produces its effect by inhibiting spermatogenesis, decreasing epididymal sperm motility, and affecting conversion of proacrosin to acrosin. Although gossypol is an effective contraceptive agent, its use is associated with side effects, the most severe of which is hypokalemic paralysis; however, this affects only about 1 % of the users. Restoration of fertility is also a matter of concern.

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