Developmental failure of pharyngeal pouches 3 and 4 is (LQ)
|B||agammaglobulinemia of Bruton,|
|C||adenosine deaminase (ADA)|
|D||combined immunodeficiency disease (SCID),|
A defect in the enzyme adenosine deaminase (ADA) is seen in the autosomal recessive form of severe combined immunodeficiency disease (SCID), while a defect in the IL-2 receptor is seen in the X-linked recessive form of SCID. A developmental defect at the pre-B stage is seen in X-linked agammaglobulinemia of Bruton, while developmental failure of pharyngeal pouches 3 and 4 is characteristic of DiGeorge’s syndrome.