Drug of choice for central diabetes insipidus is (AI -2011 )
Desmopressin is treatment of choice for central diabetes insipidus.
• It acts selectively at V2 receptors to increase urine concentration and decrease urine flow in a dose-dependent manner.
• It is also more resistant to degradation than A VP and has a three- to fourfold longer duration of action.
Desmopressin can be given by IV or SC injection, nasal inhalation, or oral tablet.