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Liver & GIT

4 out of 6

Earliest phenotypic manifestation of Idiopathic hereditary hemochromatosis is- (AIIMS May 07)

A Post prandial increase in serum iron concentration

B Elevated serum ferritin level

C Slate grey pigmentation of skin

D Increased transferrin saturation

Ans. C Slate grey pigmentation of skin

Phenotypic means manifested physical features of genome..So Ans s (C)

(Increased slate pigmentation) Because rest all A,B,D are biochemical features even though increased transferrin saturation1st feature but it is not a physical features so among option only slate pigmentation is physical feature.