Elevated IgG and IgM antibody titers to parvovirus suggest a diagnosis of which one of the following?
|A||Acute Lyme disease|
|C||Possible hepatitis B infection|
|D||Possible subacute sclerosing panencephalitis|
a. Burgdorferi, the causative agent of Lyme disease, elicits an acute antibody response. IgM appears within days to a few weeks following tick bite, and IgG appears a few weeks later. IgG persists; IgM does not. Cross-reactions occur with other treponemes.
b. Fifth disease is a viral exanthem commonly seen in children 8 to 12 years old. Children are ill for a few days but recover without incident. Unfortunately, if a pregnant female acquires the disease in the first trimester of pregnancy, the fetus is at risk. The causative agent is thought to be a Parvovirus (Parvovirus B19).
c. Adults with no titer to varicella (VZV) are at risk for acquisition of chickenpox. If they are health care workers, there is additional risk in transmitting VZV to immunodeficient children. Antibodies to VZV are readily detected by both enzyme immunoassay (EIA) and fluorescent antibody (FA) techniques.
d. Delta agent is a recently discovered antigen associated with HBSAg. Its presence usually correlates with HB5Ag chronic carriers who have chronic active hepatitis. EIA and radioimmunoassay (RIA) tests are available to detect antibodies to delta agent.
e. SSPE is thought to be caused by a measles-related virus present in the central nervous system. Most SSPE patients show elevated measles virus antibodies in serum and CSE In patients with multiple sclerosis (MS), lower CSF antibody titers have been observed, suggesting a possible etiologic role for measles virus in MS.