61 out of 91
Finasteride acts by: (DNB Dec 2011)
|C||Androgen Receptor blockade|
Ans. B 5α-reductase Inhibition
- Finasteride inhibits 5α reductase and hence reduces the circulating and prostatic Dihydrotestosterone concentration. Dihydrotestosterone is more active than testosterone. It's sites of action include prostate gland & hair follicles.
- Uses of finasteride: es prostate size after prolonged use and thus helpful in relieving the' static component' of obstruction.
- Other uses include - male pattern baldness (early stages); Hirsuitism in women
- S/E: libido, impotence, volume of ejaculate
Androgen Receptor Inhibitors:
- Cyperoterone: Used in hirsuitism in women and in cases of precocious puberty and inappropriate sexual drive in men.
- Also (-) any feed back tin LH, FSH Flutamide: Used in prostatic carcinoma Bicalutamide, Niclutamide - Orally active; Used in metastatic prostatic CA.